Hypothyroidism nke nne
Maternal hypothyroidism bu hypothyroid di n'ime nwaanyi di ime.[1]
Na agbanyeghi ezigbo ogwugwo ona itinye nne na nsogbu nakwa NWA ya. Thyroid hormone T4 na TSH, na aga n'ime placenta na aga na site na nne ruo na NWA n'ihe dika izuka 10-20 tupu NWA ahu enwe thyroid gland ma nwe Ike emeputa thyroid hormone nke ya.[2] Nne ahụ na-aga n'ihu na-enye nwa e bu n'afọ T4 ọbụlagodi mgbe o nwere ike ịmepụta nke ya. Ụmụ ọhụrụ na-arịa ọrịa hypothyroidism na-egosi na T4 dị n'ime eriri umbilical na-egosi ka nne ka na-enye pasent 25-50 nke T4. Ọ bụrụ na anaghị enyocha ụmụ ọhụrụ ndị a n'oge na-adịghị anya mgbe amuchara ha maka hypothyroidism ma gwọọ ha, ụmụ ọhụrụ ahụ nwere ike ịghọ ndị nwere nkwarụ na-adịgide adịgide, ebe ọ bụ na ha enweghị ike izute mkpa ahụ ha maka T4.[3]
Otu nnyocha gosiri na ụmụ ọhụrụ a mụrụ site na ndị nne na-agwọ hypothyroid nwere ọrụ thyroid na-adịghị mma ma e jiri ya tụnyere njikwa kwekọrọ.[2] Ya mere, a na-adụ ya ọdụ ka ọ nyochaa ọkwa T4 n'oge niile dị ime ime ọ bụrụ na a ga-amụba ọgwụgwọ iji kwado ma ihe hormone thyroid nke nne na nwa. Ọ bụrụ na nnyefe nke T4 ezughi oke nne nwere ike ịnọ n'ihe ize ndụ maka preeclampsia na ịmụ nwa tupu oge eruo.[3]
Ụmụ ọhụrụ nwekwara ike ịnọ n'ihe ize ndụ maka mmepe nke psychomotor na obere IQ.[3] N'ime nnyocha nke hypothyroidism na-akpata na òké dị ime, ha nwere ike ịchọta ọkwa dị ala nke hormone na-eto eto na ọbara na gland pituitary nke ụmụ.[4] Nnyocha a lekwara mmepe nke akwara n'ime òké wee chọpụta na hypothyroidism nke nne n'ime ụmụ òké nwere njikọ na mmebi, mmebi, disorganization na malformation nke neurons na dendrites n'ime ụmụaka, nke nwere ike ịpụta site na usoro nchebe antioxidant na ọkwa dị elu nke nrụgide oxidative.[2][4]
- ↑ Hypothyroidism in Pregnancy (en-US). American Thyroid Association. Retrieved on 2020-10-29.
- ↑ 2.0 2.1 Blazer S. (2003). "Maternal hypothyroidism may affect fetal growth and neonatal thyroid function". Obstetrics & Gynecology 102 (2): 232–241. DOI:10.1016/s0029-7844(03)00513-1. PMID 12907094. Kpọpụta njehie: Invalid
<ref>tag; name "Blazer" defined multiple times with different content - ↑ 3.0 3.1 3.2 Utiger Robert D (1999). "Editorial: Maternal Hypothyroidism and Fetal Development". The New England Journal of Medicine 341 (8): 601–2. DOI:10.1056/nejm199908193410809. PMID 10451467. Kpọpụta njehie: Invalid
<ref>tag; name "UtigerRobert" defined multiple times with different content - ↑ 4.0 4.1 Ahmed O.M. (2012). "Effects of experimentally induced maternal hypothyroidism and hyperthyroidism on the development of rat offspring: II—The developmental pattern of neurons in relation to oxidative stress and antioxidant defense system". International Journal of Developmental Neuroscience 30 (6): 517–537. DOI:10.1016/j.ijdevneu.2012.04.005. PMID 22664656.