EVT-201
EVT-201 bụ ọgwụ sitere na benzodiazepine na akụkụ ụfọdụ nke modulator allosteric nke saịtị benzodiazepin nke onye na-anabata GABAA.[1] Ọ nwere okpukpu 2-4 dị elu maka subunit α1 na subunit α2, α3, na α5 na ọrụ dị ala ma na ụdị nke ụwa họrọ site n'ime ka ndị na eme e jiri ya tụnyere benzodiazepines na-ere ahịa ugbu a na Z-ọgwụ.[2] N'agbanyeghị ịdị irè dị ala, EVT-201 ka na-egosi ịdị irè na ọgwụgwọ nke ehighị ụra nke ọma, a na-eche na ịdị irè dị obere nwere ike ịkpata mmetụta ndị ọzọ dị ala, dị ka enweghị nhazi ndị akwadoro dị ndụ ebighị ebi n'ụwa nke moto.[2] Ọ bụ Roche mepụtara ọgwụ ahụ na mbụ, dabere na data preclinical, dị ka ihe na-adịghị echegbu onwe ya, mana achọpụtara na ọ na-emepụta sedation n'ime ụmụ mmadụ na nyocha ahụike nke mbụ. N'ihi nke a, e mechara nye Evotec ikikere, nke na-emepe ya ugbu a maka ọgwụgwọ ehighị ụra.[2] As of 2007[update] afọ 2007, EVT-201 emechaala nyocha nke abụọ maka ihe ngosi a, na nchọpụta dị mma.[3] As of Ọgọstụ 2015[update] afọ , mmepe nke abụọ na-aga n'ihu na China.[4]
Hụkwa
dezie- Ndepụta ọgwụ ụra nyocha
Ntụaka
dezie- ↑ (2010) Sleep Medicine. Elsevier Health Sciences, 574–. ISBN 978-1-4377-1836-2.
- ↑ 2.0 2.1 2.2 (28 September 2010) GABA and Sleep: Molecular, Functional and Clinical Aspects. Springer Science & Business Media, 50–51. ISBN 978-3-0346-0226-6.
- ↑ (September 2007) Plunkett's Biotech & Genetics Industry Almanac 2008: Biotech & Genetics Industry Market Research, Statistics, Trends & Leading Companies. Plunkett Research, Ltd., 311–. ISBN 978-1-59392-087-6.
- ↑ Drug Profile: EVT 201. AdisInsight. Adis International Ltd, part of Springer Science+Business Media. Retrieved on 30 November 2015.
Njikọ mpụga
dezieTempleeti:Insomnia pharmacotherapiesTempleeti:Benzodiazepines