Adinazolam
Adinazolam (nke a na-ere n'okpuru aha Deracyn) bụ ihe na-eme ka obi dị jụụ nke klas triazolobenzodiazepine (TBZD), nke bụ benzodiazepines (BZDs) jikọtara ya na mgbanaka triazole. Ọ nwere ihe na-eme ka nchegbu kwụsị, ihe na-egbochi nkụchi, ihe na'egbochi ịda mbà n'obi[1][2].[3] Adinazolam bụ nke Jackson B. Hester mepụtara, onye isi oche n'ime ndị na eme Ihe ya ahazi na-achọ ịkwalite ihe ndị na-egbochi ịda mbà n'obi nke alprazolam, nke ọ mepụtara.[4] Adinazolam enwetụbeghị nkwado FDA ma ọ dịghị mgbe a kwadoro ya n'ahịa ọha na eze; Otú ọ dị, a na-ere ya dị ka ọgwụ mmepụta.[5]
Ịṅụbiga ọgwụ ókè nwere ike ịgụnye adịghị ike nke uru ahụ, ataxia, dysarthria na ọkachasị n'ime ụmụaka hụrụ ndị ọzọ ụra mbụ Nile nwere obi ụtọ, yana mbelata mmeghachi omume, mgbagwoju anya na coma nwere ike ịpụta n'ọnọdụ ndị siri ike karị.[6]
Nnyocha mmadụ na-eji mmetụta uche na ikike mmetọ nke adinazolam (30 mg na 50 mg) na diazepam, lorazepam na placebo gosipụtara ndị na eme ka anyị si nọrọ na nche megide na adinazoham na-akpata "ụbụrụ na ahụ" na "obi ọjọọ" kachasị.[7]
Pharmacodynamics na pharmacokinetics dezie
Adinazolam na-ejikọta na ụdị benzodiazepine nke na-emekọrịta ihe na ndị na-anabata GABA dị ka agonist iji mepụta mmetụta mgbochi.
Metabolism dezie
A kọrọ na Adinazolam nwere metabolites na-arụ ọrụ na mbipụta August 1984 nke The Journal of Pharmacy and Pharmacology.[8] Isi metabolite bụ N-desmethyladinazolam.[9] NDMAD nwere ihe dị ka okpukpu iri abụọ na ise dị elu maka ndị na-anabata benzodiazepine ma e jiri ya tụnyere onye bu ya ụzọ, na-akọwa mmetụta dị ka benzodiazepin mgbe a nwesịrị ọgwụ. Ọtụtụ N-dealkylations na-eduga n'iwepụ dimethylaminomethyl n'akụkụ, na-edughachi na ọdịiche dị na ike ya.[9] Abụọ ndị ọzọ metabolites bụ alpha-hydroxyalprazolam na estazolam.[10] Na mbipụta August 1986 nke otu akwụkwọ akụkọ ahụ, Sethy, Francis na Day kọrọ na proadifen gbochiri mmepụta nke N-desmethyladinazolam.[11]
Hụkwa dezie
- Benzodiazepine
- Alprazolam
- Fluadinazolam
- GL-II-73
Ntụaka dezie
- ↑ (June 1987) "Adinazolam--a new antidepressant: findings of a placebo-controlled, double-blind study in outpatients with major depression". Journal of Clinical Psychopharmacology 7 (3): 170–172. DOI:10.1097/00004714-198706000-00010. PMID 3298327.
- ↑ (November 1983) "Pharmacological profile of the antidepressant adinazolam, a triazolobenzodiazepine". Neuropharmacology 22 (11): 1277–1282. DOI:10.1016/0028-3908(83)90200-9. PMID 6320036.
- ↑ (March 1998) "Kinetic characterization and identification of the enzymes responsible for the hepatic biotransformation of adinazolam and N-desmethyladinazolam in man". The Journal of Pharmacy and Pharmacology 50 (3): 265–274. DOI:10.1111/j.2042-7158.1998.tb06859.x. PMID 9600717.
- ↑ Discovers Award 2004. Special Publications 39. Pharmaceutical Research and Manufacturers of America (April 2004). Archived from the original on August 24, 2006. Retrieved on August 18, 2006.
- ↑ (November 2016) "Characterization and in vitro phase I microsomal metabolism of designer benzodiazepines - an update comprising adinazolam, cloniprazepam, fonazepam, 3-hydroxyphenazepam, metizolam and nitrazolam". Journal of Mass Spectrometry 51 (11): 1080–1089. DOI:10.1002/jms.3840. PMID 27535017.
- ↑ Adinazolam. DrugBank.
- ↑ The Abuse Potential of Adinazolam: A Comparison with Diazepam, Lorazepam and Placebo. NIDA Research Monograph No. 81 (1987). Archived from the original on 2016-12-22. Retrieved on 2015-12-17.
- ↑ (August 1984) "Determination of biological activity of adinazolam and its metabolites". The Journal of Pharmacy and Pharmacology 36 (8): 546–548. DOI:10.1111/j.2042-7158.1984.tb04449.x. PMID 6148400.
- ↑ 9.0 9.1 (August 1984) "Assay of adinazolam in plasma by liquid chromatography". Journal of Pharmaceutical Sciences 73 (8): 1173–1175. DOI:10.1002/jps.2600730840. PMID 6491930.
- ↑ (November–December 1993) "Urinary screening for adinazolam and its major metabolites by the Emit d.a.u. and FPIA benzodiazepine assays with confirmation by HPLC". Journal of Analytical Toxicology 17 (7): 427–431. DOI:10.1093/jat/17.7.427. PMID 8309217.
- ↑ (August 1986) "The effect of proadifen on the metabolism of adinazolam". The Journal of Pharmacy and Pharmacology 38 (8): 631–632. DOI:10.1111/j.2042-7158.1986.tb03099.x. PMID 2876087.